MolNFT v1 · #427857 · protein

AlphaFold monomer V2.0 prediction for sphingosine-1-phosphate lyase 1 (O95470)

O95470: “AlphaFold monomer V2.0 prediction for sphingosine-1-phosphate lyase 1 (O95470)”. 7 pockets (best druggability 0.62). MolNFT v1 #427857 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: O95470
Type: protein
Length: 568 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x1647F35A28688000958944B2f9d235C7c91d22B9
Molecule: Sphingosine-1-phosphate lyase 1
UniProt: O95470
Pockets: 7 · best druggability 0.62

Structure

1 distinct chain · 51% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sphingosine-1-phosphate lyase 1	protein	568	51% helix, 11% strand	O95470

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	474	0.62	0.76	48	empty
2	162	0.48	0.77	23	empty
3	117	0.45	0.78	20	empty
4	60	0.42	0.81	16	empty
5	78	0.39	0.78	25	empty

Compared structures

8AYF · Crystal structure of human Sphingosine-1-phosphate lyase 1 · an experimental structure of the same protein · chain A against B, TM-score 0.79
4Q6R · Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor… · an experimental structure of the same protein · chain A against B, TM-score 0.78
4Q6R · Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor… · an experimental structure of the same protein · chain A against B, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95470
Elsewhere: UniProt O95470 · AlphaFold DB O95470

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