UniProt O95470
Sphingosine-1-phosphate lyase 1 (O95470)
Sphingosine-1-phosphate lyase 1 (UniProt O95470), EC 4.1.2.27: 3 experimental structures and 1 predicted model on GenesisL1, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95470
- Protein
- Sphingosine-1-phosphate lyase 1
- EC
- 4.1.2.27
- Experimental structures
- 3
- Predicted models
- 1
- Pockets
- 21 · 2 records with a druggable one
Structures
4 records of O95470 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4Q6R | Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor… | x-ray diffraction | A, B | — | — |
| 4Q6R | Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor… | x-ray diffraction | A, B | — | — |
| 8AYF | Crystal structure of human Sphingosine-1-phosphate lyase 1 | x-ray diffraction | A, B | — | 14 (best 0.79) |
| O95470 | AlphaFold monomer V2.0 prediction for sphingosine-1-phosphate lyase 1 (O95470) | predicted | A | — | 7 (best 0.62) |
Experiment against prediction
- 4Q6R chain A against the predicted model O95470: TM-score 1.00, RMSD 0.25 Å
- 4Q6R chain A against the predicted model O95470: TM-score 1.00, RMSD 0.25 Å
- 8AYF chain B against the predicted model O95470: TM-score 1.00, RMSD 0.36 Å
- 4Q6R chain B against the predicted model O95470: TM-score 1.00, RMSD 0.37 Å
- 4Q6R chain B against the predicted model O95470: TM-score 1.00, RMSD 0.37 Å
- 8AYF chain A against the predicted model O95470: TM-score 1.00, RMSD 0.42 Å
Elsewhere
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