MolNFT v1 · #427812 · protein
AlphaFold monomer V2.0 prediction for sigma non-opioid intracellular receptor 1 (Q99720)
Q99720: “AlphaFold monomer V2.0 prediction for sigma non-opioid intracellular receptor 1 (Q99720)”. 2 pockets (best druggability 0.83). MolNFT v1 #427812 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q99720
- Type
- protein
- Length
- 223 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xa035E6D3B1efC66Af27788374F32B4851461992f
- Molecule
- Sigma non-opioid intracellular receptor 1
- UniProt
- Q99720
- Pockets
- 2 · best druggability 0.83
Structure
1 distinct chain · 43% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sigma non-opioid intracellular receptor 1 | protein | 223 | 43% helix, 28% strand | Q99720 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 218 | 0.83 | 0.96 | 37 | empty |
| 2 | 70 | 0.28 | 0.72 | 17 | empty |
Compared structures
- 6DK1 · Human sigma-1 receptor bound to (+)-pentazocine · an experimental structure of the same protein · chain A against C, TM-score 0.87
- 6DK0 · Human sigma-1 receptor bound to ne-100 · an experimental structure of the same protein · chain A against C, TM-score 0.86
- 6DK0 · Human sigma-1 receptor bound to NE-100 · an experimental structure of the same protein · chain A against C, TM-score 0.86
- 6DJZ · Human sigma-1 receptor bound to haloperidol · an experimental structure of the same protein · chain A against C, TM-score 0.86
- 5HK2 · Human sigma-1 receptor bound to 4-IBP · an experimental structure of the same protein · chain A against B, TM-score 0.86
- 5HK2 · Human sigma-1 receptor bound to 4-ibp · an experimental structure of the same protein · chain A against B, TM-score 0.86
- 5HK1 · Human sigma-1 receptor bound to PD144418 · an experimental structure of the same protein · chain A against C, TM-score 0.86
- 5HK1 · Human sigma-1 receptor bound to PD144418 · an experimental structure of the same protein · chain A against C, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99720
- Elsewhere: UniProt Q99720 · AlphaFold DB Q99720
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