UniProt Q99720
Sigma non-opioid intracellular receptor 1 (Q99720)
Sigma non-opioid intracellular receptor 1 (UniProt Q99720): 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q99720
- Protein
- Sigma non-opioid intracellular receptor 1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 10 · 2 records with a druggable one
Structures
9 records of Q99720 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5HK1 | Human sigma-1 receptor bound to PD144418 | x-ray diffraction | A, B, C | 61W, SO4 | — |
| 5HK1 | Human sigma-1 receptor bound to PD144418 | x-ray diffraction | A, B, C | — | — |
| 5HK2 | Human sigma-1 receptor bound to 4-IBP | x-ray diffraction | A, B, C | 61V, SO4 | 8 (best 0.85) |
| 5HK2 | Human sigma-1 receptor bound to 4-ibp | x-ray diffraction | A, B, C | — | — |
| 6DJZ | Human sigma-1 receptor bound to haloperidol | x-ray diffraction | A, B, C | GMJ, SO4 | — |
| 6DK0 | Human sigma-1 receptor bound to NE-100 | x-ray diffraction | A, B, C | GKY, SO4 | — |
| 6DK0 | Human sigma-1 receptor bound to ne-100 | x-ray diffraction | A, B, C | GKY, SO4 | — |
| 6DK1 | Human sigma-1 receptor bound to (+)-pentazocine | x-ray diffraction | A, B, C | GM4, SO4 | — |
| Q99720 | AlphaFold monomer V2.0 prediction for sigma non-opioid intracellular receptor 1 (Q99720) | predicted | A | — | 2 (best 0.83) |
Ligands
- SO4 · Sulfate ion · in 6 records
- GKY · N-{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}-N-propylpropan-1-amine · in 2 records
- 61V · N-(1-benzylpiperidin-4-yl)-4-iodobenzamide · in 1 record
- 61W · 3-(4-methylphenyl)-5-(1-propyl-3,6-dihydro-2H-pyridin-5-yl)-1,2-oxazole · in 1 record
- GM4 · (2S,6S,11S)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1, 2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol · in 1 record
- GMJ · 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one · in 1 record
Experiment against prediction
- 5HK2 chain B against the predicted model Q99720: TM-score 0.91, RMSD 2.08 Å
- 5HK2 chain B against the predicted model Q99720: TM-score 0.91, RMSD 2.08 Å
- 6DK1 chain A against the predicted model Q99720: TM-score 0.89, RMSD 1.77 Å
- 5HK1 chain A against the predicted model Q99720: TM-score 0.89, RMSD 1.67 Å
- 5HK1 chain A against the predicted model Q99720: TM-score 0.89, RMSD 1.67 Å
- 6DJZ chain A against the predicted model Q99720: TM-score 0.89, RMSD 1.67 Å
- 6DK0 chain A against the predicted model Q99720: TM-score 0.89, RMSD 1.67 Å
- 6DK0 chain A against the predicted model Q99720: TM-score 0.89, RMSD 1.67 Å
- 5HK2 chain C against the predicted model Q99720: TM-score 0.89, RMSD 1.68 Å
- 5HK2 chain C against the predicted model Q99720: TM-score 0.89, RMSD 1.68 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.