MolNFT v1 · #426783 · protein
AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD1B (Q9UPS6)
Q9UPS6: “AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD1B (Q9UPS6)”. 5 pockets (best druggability 0.66). MolNFT v1 #426783 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9UPS6
- Type
- protein
- Length
- 1,966 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x40ceAE928a79502748126799cBFF9492DaA1C4BA
- Molecule
- Histone-lysine N-methyltransferase SETD1B
- UniProt
- Q9UPS6
- Pockets
- 5 · best druggability 0.66
Structure
1 distinct chain · 10% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase SETD1B | protein | 1966 | 10% helix, 5% strand | Q9UPS6 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 423 | 0.66 | 0.78 | 45 | empty |
| 2 | 172 | 0.48 | 0.76 | 22 | empty |
| 3 | 134 | 0.41 | 0.75 | 20 | empty |
| 4 | 120 | 0.38 | 0.74 | 16 | empty |
| 5 | 80 | 0.32 | 0.74 | 11 | empty |
Compared structures
- 3UVO · Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B · an experimental structure of the same protein · chain A against B, TM-score 0.00
- 3UVO · Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B · an experimental structure of the same protein · chain A against B, TM-score 0.00
- 4ES0 · X-ray structure of WDR5-SETd1b Win motif peptide binary complex · an experimental structure of the same protein · chain A against C, TM-score 0.00
- 4ES0 · X-ray structure of WDR5-SETD1B win motif peptide binary complex · an experimental structure of the same protein · chain A against C, TM-score 0.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UPS6
- Elsewhere: UniProt Q9UPS6 · AlphaFold DB Q9UPS6
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