UniProt Q9UPS6
Histone-lysine N-methyltransferase SETD1B (Q9UPS6)
Histone-lysine N-methyltransferase SETD1B (UniProt Q9UPS6), EC 2.1.1.364: 5 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UPS6
- Protein
- Histone-lysine N-methyltransferase SETD1B
- EC
- 2.1.1.364
- Experimental structures
- 5
- Predicted models
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
6 records of Q9UPS6 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UVO | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B | x-ray diffraction | B | — | — |
| 3UVO | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B | x-ray diffraction | B | — | — |
| 4ES0 | X-ray structure of WDR5-SETd1b Win motif peptide binary complex | x-ray diffraction | C | — | — |
| 4ES0 | X-ray structure of WDR5-SETD1B win motif peptide binary complex | x-ray diffraction | C | — | — |
| 8ILZ | Crystal structure of the RRM domain of human SETD1B | x-ray diffraction | A | — | — |
| Q9UPS6 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD1B (Q9UPS6) | predicted | A | — | 5 (best 0.66) |
Experiment against prediction
- 8ILZ chain A against the predicted model Q9UPS6: TM-score 0.98, RMSD 0.61 Å
- 4ES0 chain C against the predicted model Q9UPS6: TM-score 0.79, RMSD 0.28 Å
- 4ES0 chain C against the predicted model Q9UPS6: TM-score 0.79, RMSD 0.28 Å
- 3UVO chain B against the predicted model Q9UPS6: TM-score 0.49, RMSD 1.57 Å
- 3UVO chain B against the predicted model Q9UPS6: TM-score 0.49, RMSD 1.57 Å
Elsewhere
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