MolNFT v1 · #423416 · protein
AlphaFold monomer V2.0 prediction for rab guanine nucleotide exchange factor SEC2 (P17065)
P17065: “AlphaFold monomer V2.0 prediction for rab guanine nucleotide exchange factor SEC2 (P17065)”. 4 pockets (best druggability 0.57). MolNFT v1 #423416 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P17065
- Type
- protein
- Length
- 759 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7012c0b45c68a2c067644b9d3e5DDa06892c6957
- Molecule
- Rab guanine nucleotide exchange factor SEC2
- UniProt
- P17065
- Pockets
- 4 · best druggability 0.57
Structure
1 distinct chain · 42% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rab guanine nucleotide exchange factor SEC2 | protein | 759 | 42% helix, 3% strand | P17065 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.57 | 0.78 | 39 | empty |
| 2 | 190 | 0.47 | 0.75 | 25 | empty |
| 3 | 80 | 0.40 | 0.78 | 21 | empty |
| 4 | 53 | 0.30 | 0.75 | 13 | empty |
Compared structures
- 2OCY · Complex of the guanine exchange factor Sec2p and the Rab GTPase Sec4p · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2OCY · Complex of the guanine exchange factor SEC2P and the rab GTPase SEC4P · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 2E7S · Crystal structure of the yeast Sec2p GEF domain · an experimental structure of the same protein · chain A against B, TM-score 0.13
- 2E7S · Crystal structure of the yeast SEC2P gef domain · an experimental structure of the same protein · chain A against B, TM-score 0.13
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17065
- Elsewhere: UniProt P17065 · AlphaFold DB P17065
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