UniProt P17065
Rab guanine nucleotide exchange factor SEC2 (P17065)
Rab guanine nucleotide exchange factor SEC2 (UniProt P17065): 8 experimental structures and 1 predicted model on GenesisL1, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P17065
- Protein
- Rab guanine nucleotide exchange factor SEC2
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
9 records of P17065 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2E7S | Crystal structure of the yeast Sec2p GEF domain | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | — |
| 2E7S | Crystal structure of the yeast SEC2P gef domain | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | — |
| 2EQB | Crystal structure of the Rab GTPase Sec4p, the Sec2p GEF domain, and phosphate complex | x-ray diffraction | B, C | — | — |
| 2EQB | Crystal structure of the rab GTPase SEC4P, the SEC2P gef domain, and phosphate complex | x-ray diffraction | B, C | — | — |
| 2OCY | Complex of the guanine exchange factor Sec2p and the Rab GTPase Sec4p | x-ray diffraction | A, B | — | — |
| 2OCY | Complex of the guanine exchange factor SEC2P and the rab GTPase SEC4P | x-ray diffraction | A, B | — | — |
| 4ZDW | Crystal structure of the Rab GTPase Sec4p mutant - S29V in complex with Sec2p and GDP | x-ray diffraction | B, C | — | — |
| 4ZDW | Crystal structure of the rab GTPase SEC4P mutant - S29V in complex with SEC2P and GDP | x-ray diffraction | B, C | — | — |
| P17065 | AlphaFold monomer V2.0 prediction for rab guanine nucleotide exchange factor SEC2 (P17065) | predicted | A | — | 4 (best 0.57) |
Experiment against prediction
- 2EQB chain B against the predicted model P17065: TM-score 0.85, RMSD 1.58 Å
- 2EQB chain B against the predicted model P17065: TM-score 0.85, RMSD 1.58 Å
- 4ZDW chain B against the predicted model P17065: TM-score 0.83, RMSD 1.72 Å
- 4ZDW chain B against the predicted model P17065: TM-score 0.83, RMSD 1.72 Å
- 2E7S chain H against the predicted model P17065: TM-score 0.75, RMSD 2.53 Å
- 2E7S chain H against the predicted model P17065: TM-score 0.75, RMSD 2.53 Å
- 2E7S chain N against the predicted model P17065: TM-score 0.74, RMSD 2.61 Å
- 2E7S chain N against the predicted model P17065: TM-score 0.74, RMSD 2.61 Å
- 2E7S chain A against the predicted model P17065: TM-score 0.73, RMSD 2.55 Å
- 2E7S chain A against the predicted model P17065: TM-score 0.73, RMSD 2.55 Å
Elsewhere
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