MolNFT v1 · #421921 · protein
AlphaFold monomer V2.0 prediction for methylmalonyl-CoA decarboxylase (P52045)
P52045: “AlphaFold monomer V2.0 prediction for methylmalonyl-CoA decarboxylase (P52045)”. 4 pockets (best druggability 0.57). MolNFT v1 #421921 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P52045
- Type
- protein
- Length
- 261 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7FDF8b382C6a36A8772D1A265E8e480c7DF0A9C1
- Molecule
- Methylmalonyl-CoA decarboxylase
- UniProt
- P52045
- Pockets
- 4 · best druggability 0.57
Structure
1 distinct chain · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methylmalonyl-CoA decarboxylase | protein | 261 | 46% helix, 16% strand | P52045 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.57 | 0.81 | 28 | empty |
| 2 | 200 | 0.53 | 0.78 | 24 | empty |
| 3 | 158 | 0.42 | 0.73 | 24 | empty |
| 4 | 123 | 0.41 | 0.75 | 23 | empty |
Compared structures
- 6N96 · Methylmalonyl-CoA decarboxylase in complex with 2-sulfonate-propionyl-oxa(dethia)-CoA · an experimental structure of the same protein · chain A against F, TM-score 1.00
- 6N95 · Methylmalonyl-CoA decarboxylase in complex with 2-sulfonate-propionyl-CoA · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 6N95 · Methylmalonyl-CoA decarboxylase in complex with 2-sulfonate-propionyl- CoA · an experimental structure of the same protein · chain A against A, TM-score 1.00
- 6N94 · Methylmalonyl-CoA decarboxylase in complex with 2-nitronate-propionyl-amino(dethia)-CoA · an experimental structure of the same protein · chain A against E, TM-score 0.99
- 6N96 · Methylmalonyl-CoA decarboxylase in complex with 2-sulfonate-propionyl- OXA(DETHIA)-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6N97 · Methylmalonyl-CoA decarboxylase in complex with 2-sulfonate-propionyl- AMINO(DETHIA)-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6N97 · Methylmalonyl-CoA decarboxylase in complex with 2-sulfonate-propionyl-amino(dethia)-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.99
- 6N94 · Methylmalonyl-CoA decarboxylase in complex with 2-nitronate-propionyl- AMINO(DETHIA)-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52045
- Elsewhere: UniProt P52045 · AlphaFold DB P52045
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.