MolNFT v1 · #421494 · protein
AlphaFold monomer V2.0 prediction for sodium channel protein type 2 subunit alpha (Q99250)
Q99250: “AlphaFold monomer V2.0 prediction for sodium channel protein type 2 subunit alpha (Q99250)”. 20 pockets (best druggability 0.87). MolNFT v1 #421494 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q99250
- Type
- protein
- Length
- 2,005 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3CD694Bb4B687b1E23f95579904aDaE5a32c9FE0
- Molecule
- Sodium channel protein type 2 subunit alpha
- UniProt
- Q99250
- Pockets
- 20 · best druggability 0.87
Structure
1 distinct chain · 53% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein type 2 subunit alpha | protein | 2005 | 53% helix, 3% strand | Q99250 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1123 | 0.87 | 0.87 | 88 | empty |
| 2 | 1114 | 0.73 | 0.76 | 79 | empty |
| 3 | 585 | 0.72 | 0.80 | 53 | empty |
| 4 | 531 | 0.68 | 0.78 | 44 | empty |
| 5 | 412 | 0.67 | 0.80 | 40 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6J8E · Human Nav1.2-beta2-KIIIA ternary complex · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 6J8E · Human NAV1.2-BETA2-kiiia ternary complex · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 4JPZ · Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and… · an experimental structure of the same protein · chain A against B, TM-score 0.06
- 4JPZ · Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and… · an experimental structure of the same protein · chain A against B, TM-score 0.06
- 2KAV · Solution structure of the human Voltage-gated Sodium Channel, brain isoform (Nav1.2) · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2KAV · Solution structure of the human voltage-gated sodium channel, brain isoform (NAV1.2) · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 6BUT · Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the… · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 6BUT · Solution structure of full-length apo mammalian calmodulin bound to the iq motif of the… · an experimental structure of the same protein · chain A against B, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99250
- Elsewhere: UniProt Q99250 · AlphaFold DB Q99250
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