UniProt Q99250
Sodium channel protein type 2 subunit alpha (Q99250)
Sodium channel protein type 2 subunit alpha (UniProt Q99250): 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q99250
- Protein
- Sodium channel protein type 2 subunit alpha
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 21 · 2 records with a druggable one
Structures
8 records of Q99250 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KAV | Solution structure of the human Voltage-gated Sodium Channel, brain isoform (Nav1.2) | solution nmr | A | — | — |
| 2KAV | Solution structure of the human voltage-gated sodium channel, brain isoform (NAV1.2) | solution nmr | A | — | — |
| 4JPZ | Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin | x-ray diffraction | B, H | — | — |
| 4JPZ | Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and CA2+/CALMODULIN | x-ray diffraction | B, H | — | — |
| 6BUT | Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human… | solution nmr | B | — | 1 (best 0.52) |
| 6BUT | Solution structure of full-length apo mammalian calmodulin bound to the iq motif of the human… | solution nmr | B | — | — |
| 6J8E | Human NAV1.2-BETA2-kiiia ternary complex | electron microscopy | A | NAG, BMA, 9Z9, NA | — |
| Q99250 | AlphaFold monomer V2.0 prediction for sodium channel protein type 2 subunit alpha (Q99250) | predicted | A | — | 20 (best 0.87) |
Ligands
Experiment against prediction
- 6J8E chain A against the predicted model Q99250: TM-score 0.98, RMSD 1.71 Å
- 2KAV chain A against the predicted model Q99250: TM-score 0.78, RMSD 2.18 Å
- 2KAV chain A against the predicted model Q99250: TM-score 0.78, RMSD 2.18 Å
- 4JPZ chain B against the predicted model Q99250: TM-score 0.72, RMSD 2.52 Å
- 4JPZ chain B against the predicted model Q99250: TM-score 0.72, RMSD 2.52 Å
- 6BUT chain B against the predicted model Q99250: TM-score 0.62, RMSD 1.77 Å
- 6BUT chain B against the predicted model Q99250: TM-score 0.62, RMSD 1.77 Å
Elsewhere
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