MolNFT v1 · #421056 · protein
AlphaFold monomer V2.0 prediction for sodium-dependent dopamine transporter (Q01959)
Q01959: “AlphaFold monomer V2.0 prediction for sodium-dependent dopamine transporter (Q01959)”. 5 pockets (best druggability 0.79). MolNFT v1 #421056 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q01959
- Type
- protein
- Length
- 620 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x79a905d858Ce72991FD6E7a9C6498620f42E146D
- Molecule
- Sodium-dependent dopamine transporter
- UniProt
- Q01959
- Pockets
- 5 · best druggability 0.79
Structure
1 distinct chain · 67% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium-dependent dopamine transporter | protein | 620 | 67% helix, 2% strand | Q01959 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 707 | 0.79 | 0.83 | 59 | empty |
| 2 | 301 | 0.56 | 0.76 | 37 | empty |
| 3 | 115 | 0.40 | 0.76 | 21 | empty |
| 4 | 73 | 0.36 | 0.75 | 13 | empty |
| 5 | 52 | 0.35 | 0.79 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 9EO4 · Outward-open structure of human dopamine transporter bound to cocaine · an experimental structure of the same protein · chain A against B, TM-score 0.87
- 8Y2G · Cryo-EM structure of human dopamine transporter in complex with methylphenidate · an experimental structure of the same protein · chain A against A, TM-score 0.86
- 8Y2D · Cryo-EM structure of human dopamine transporter in complex with dopamine · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 8Y2F · Cryo-EM structure of human dopamine transporter in complex with GBR12909 · an experimental structure of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01959
- Elsewhere: UniProt Q01959 · AlphaFold DB Q01959
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