UniProt Q01959
Sodium-dependent dopamine transporter (Q01959)
Sodium-dependent dopamine transporter (UniProt Q01959): 6 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q01959
- Protein
- Sodium-dependent dopamine transporter
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 41 · 7 records with a druggable one
Structures
7 records of Q01959 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8VBY | Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc | electron microscopy | A | 42L, A1AAF, NAG, Y01, D10, LNK | 6 (best 0.83) |
| 8Y2D | Cryo-EM structure of human dopamine transporter in complex with dopamine | electron microscopy | A | LDP, NA, CL | 6 (best 0.78) |
| 8Y2E | Cryo-EM structure of human dopamine transporter in complex with benztropine | electron microscopy | A | NAG, CXQ | 6 (best 0.76) |
| 8Y2F | Cryo-EM structure of human dopamine transporter in complex with GBR12909 | electron microscopy | A | A1D5S, NAG | 7 (best 0.77) |
| 8Y2G | Cryo-EM structure of human dopamine transporter in complex with methylphenidate | electron microscopy | A | A1D5U, NAG, CL, NA | 5 (best 0.79) |
| 9EO4 | Outward-open structure of human dopamine transporter bound to cocaine | electron microscopy | B | CLR, Y01, NA, CL, COC | 6 (best 0.81) |
| Q01959 | AlphaFold monomer V2.0 prediction for sodium-dependent dopamine transporter (Q01959) | predicted | A | — | 5 (best 0.79) |
Ligands
- NA · Sodium ion · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- CL · Chloride ion · in 3 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- 42L · methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate · in 1 record
- A1AAF · methyl (1S,2R,3S,4R,5R)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9H-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate · in 1 record
- A1D5S · Vanoxerine · in 1 record
- A1D5U · Dexmethylphenidate · in 1 record
- CLR · Cholesterol · in 1 record
- COC · Cocaine · in 1 record
- CXQ · benztropine · in 1 record
- D10 · Decane · in 1 record
- D12 · Dodecane · in 1 record
- HP6 · Heptane · in 1 record
- LDP · L-dopamine · in 1 record
- LNK · Pentane · in 1 record
- MYS · Pentadecane · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 9EO4 chain B against the predicted model Q01959: TM-score 0.98, RMSD 1.06 Å
- 8Y2G chain A against the predicted model Q01959: TM-score 0.97, RMSD 1.45 Å
- 8VBY chain A against the predicted model Q01959: TM-score 0.97, RMSD 1.60 Å
- 8Y2D chain A against the predicted model Q01959: TM-score 0.97, RMSD 1.57 Å
- 8Y2F chain A against the predicted model Q01959: TM-score 0.95, RMSD 1.94 Å
- 8Y2E chain A against the predicted model Q01959: TM-score 0.94, RMSD 2.18 Å
Elsewhere
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