MolNFT v1 · #421053 · protein
AlphaFold monomer V2.0 prediction for sodium-dependent noradrenaline transporter (P23975)
P23975: “AlphaFold monomer V2.0 prediction for sodium-dependent noradrenaline transporter (P23975)”. 7 pockets (best druggability 0.81). MolNFT v1 #421053 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P23975
- Type
- protein
- Length
- 617 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x08ded9906AC7e19C6B7AAb656B69692055A6199f
- Molecule
- Sodium-dependent noradrenaline transporter
- UniProt
- P23975
- Pockets
- 7 · best druggability 0.81
Structure
1 distinct chain · 68% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium-dependent noradrenaline transporter | protein | 617 | 68% helix, 3% strand | P23975 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.81 | 0.82 | 80 | empty |
| 2 | 84 | 0.45 | 0.80 | 16 | empty |
| 3 | 87 | 0.43 | 0.80 | 18 | empty |
| 4 | 103 | 0.38 | 0.75 | 17 | empty |
| 5 | 71 | 0.34 | 0.75 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 8WTV · Cryo-EM structure of noradrenaline transporter in complex with noradrenaline · an experimental structure of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23975
- Elsewhere: UniProt P23975 · AlphaFold DB P23975
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