UniProt P23975
Sodium-dependent noradrenaline transporter (P23975)
Sodium-dependent noradrenaline transporter (UniProt P23975): 9 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 63 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P23975
- Protein
- Sodium-dependent noradrenaline transporter
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 63 · 10 records with a druggable one
Structures
10 records of P23975 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8HFL | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant… | electron microscopy | A | 1XR, CL | 6 (best 0.79) |
| 8WGR | Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with… | electron microscopy | A | DSM, CL, K | 6 (best 0.81) |
| 8WGX | Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with… | electron microscopy | A | LNR | 5 (best 0.79) |
| 8WTV | Cryo-EM structure of noradrenaline transporter in complex with noradrenaline | electron microscopy | A | NA, CL, E5E, NAG | 6 (best 0.80) |
| 8WTW | Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue | electron microscopy | A | CL, NA | 6 (best 0.83) |
| 8WTX | Cryo-EM structure of noradrenaline transporter in complex with bupropion | electron microscopy | A | Y60 | 8 (best 0.81) |
| 8XB3 | Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter | electron microscopy | A | YMN, NAG | 5 (best 0.76) |
| 8Y8Z | Structure of NET-Maprotiline in outward-open state | electron microscopy | A, E | A1LX3, NA, CL | 10 (best 0.82) |
| 8Y92 | structure of NET-Atomoxetine in outward-open state | electron microscopy | A, B | A1LX4, CL, NA | 4 (best 0.80) |
| P23975 | AlphaFold monomer V2.0 prediction for sodium-dependent noradrenaline transporter (P23975) | predicted | A | — | 7 (best 0.81) |
Ligands
- CL · Chloride ion · in 6 records
- NA · Sodium ion · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- 1XR · Bupropion · in 1 record
- A1LX3 · ~{N}-methyl-3-(1-tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9,11,13-hexaenyl)propan-1-amine · in 1 record
- A1LX4 · (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine · in 1 record
- DSM · 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine · in 1 record
- E5E · Noradrenaline · in 1 record
- K · Potassium ion · in 1 record
- LNR · L-norepinephrine · in 1 record
- Y60 · (2~{R})-2-(~{tert}-butylamino)-1-(3-chlorophenyl)propan-1-one · in 1 record
- YMN · Iobenguane · in 1 record
Experiment against prediction
- 8Y92 chain A against the predicted model P23975: TM-score 0.98, RMSD 1.20 Å
- 8Y92 chain B against the predicted model P23975: TM-score 0.98, RMSD 1.21 Å
- 8Y8Z chain A against the predicted model P23975: TM-score 0.97, RMSD 1.28 Å
- 8Y8Z chain E against the predicted model P23975: TM-score 0.97, RMSD 1.29 Å
- 8WTW chain A against the predicted model P23975: TM-score 0.97, RMSD 1.44 Å
- 8XB3 chain A against the predicted model P23975: TM-score 0.96, RMSD 1.85 Å
- 8WTV chain A against the predicted model P23975: TM-score 0.95, RMSD 1.93 Å
- 8WTX chain A against the predicted model P23975: TM-score 0.95, RMSD 1.93 Å
- 8WGX chain A against the predicted model P23975: TM-score 0.95, RMSD 2.07 Å
- 8WGR chain A against the predicted model P23975: TM-score 0.95, RMSD 2.07 Å
Elsewhere
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