MolNFT v1 · #386625 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q8YPK3)
Q8YPK3: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q8YPK3)”. 4 pockets (best druggability 0.43). MolNFT v1 #386625 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8YPK3
- Type
- protein
- Length
- 315 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x213e8bCc83C1146cc6838177a90617A33039bB6A
- Molecule
- DNA-directed RNA polymerase subunit alpha
- UniProt
- Q8YPK3
- Pockets
- 4 · best druggability 0.43
Structure
1 distinct chain · 29% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase subunit alpha | protein | 315 | 29% helix, 32% strand | Q8YPK3 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.43 | 0.78 | 21 | empty |
| 2 | 62 | 0.41 | 0.81 | 19 | empty |
| 3 | 67 | 0.34 | 0.76 | 16 | empty |
| 4 | 61 | 0.29 | 0.72 | 12 | empty |
Compared structures
- 8H40 · Cryo-EM structure of the transcription activation complex NtcA-TAC · an experimental structure of the same protein · chain A against D, TM-score 0.68
- 8H3V · Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC · an experimental structure of the same protein · chain A against C, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8YPK3
- Elsewhere: UniProt Q8YPK3 · AlphaFold DB Q8YPK3
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