UniProt Q8YPK3
DNA-directed RNA polymerase subunit alpha (Q8YPK3)
DNA-directed RNA polymerase subunit alpha (UniProt Q8YPK3), EC 2.7.7.6: 2 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8YPK3
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 2
- Predicted models
- 1
- Pockets
- 10 · 2 records with a druggable one
Structures
3 records of Q8YPK3 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8H3V | Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC | electron microscopy | C, D | — | 2 (best 0.80) |
| 8H40 | Cryo-EM structure of the transcription activation complex NtcA-TAC | electron microscopy | C, D | — | 4 (best 0.80) |
| Q8YPK3 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q8YPK3) | predicted | A | — | 4 (best 0.43) |
Experiment against prediction
- 8H40 chain D against the predicted model Q8YPK3: TM-score 0.94, RMSD 1.70 Å
- 8H40 chain C against the predicted model Q8YPK3: TM-score 0.94, RMSD 1.90 Å
- 8H3V chain C against the predicted model Q8YPK3: TM-score 0.92, RMSD 1.89 Å
- 8H3V chain D against the predicted model Q8YPK3: TM-score 0.92, RMSD 1.95 Å
Elsewhere
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