MolNFT v1 · #385095 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC3 (P32349)
P32349: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC3 (P32349)”. 9 pockets (best druggability 0.79). MolNFT v1 #385095 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P32349
- Type
- protein
- Length
- 654 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x429aA010A80A47FF4a2777bB34A2bba144d19df2
- Molecule
- DNA-directed RNA polymerase III subunit RPC3
- UniProt
- P32349
- Pockets
- 9 · best druggability 0.79
Structure
1 distinct chain · 57% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase III subunit RPC3 | protein | 654 | 57% helix, 8% strand | P32349 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 456 | 0.79 | 0.87 | 37 | empty |
| 2 | 607 | 0.68 | 0.77 | 56 | empty |
| 3 | 228 | 0.50 | 0.75 | 19 | empty |
| 4 | 108 | 0.48 | 0.80 | 14 | empty |
| 5 | 88 | 0.40 | 0.77 | 19 | empty |
Compared structures
- 7Z1L · Structure of yeast RNA Polymerase III Pre-Termination Complex (PTC) · an experimental structure of the same protein · chain A against O, TM-score 0.84
- 7Z1O · Structure of yeast RNA Polymerase III PTC + NTPs · an experimental structure of the same protein · chain A against O, TM-score 0.84
- 7Z1M · Structure of yeast RNA Polymerase III Elongation Complex (EC) · an experimental structure of the same protein · chain A against O, TM-score 0.84
- 8BWS · Structure of yeast RNA Polymerase III elongation complex at 3.3 A · an experimental structure of the same protein · chain A against O, TM-score 0.84
- 7Z1N · Structure of yeast RNA Polymerase III Delta C53-C37-C11 · an experimental structure of the same protein · chain A against O, TM-score 0.84
- 7Z1N · Structure of yeast RNA polymerase III delta C53-C37-C11 · an experimental structure of the same protein · chain A against O, TM-score 0.84
- 7Z2Z · Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A · an experimental structure of the same protein · chain A against O, TM-score 0.84
- 6TUT · Cryo-EM structure of the RNA polymerase III-MAF1 complex · an experimental structure of the same protein · chain A against O, TM-score 0.82
- 6TUT · Cryo-EM structure of the RNA Polymerase III-Maf1 complex · an experimental structure of the same protein · chain A against O, TM-score 0.82
- 6EU0 · RNA polymerase III open pre-initiation complex (oc-pic) · an experimental structure of the same protein · chain A against O, TM-score 0.80
- 6EU0 · RNA Polymerase III open pre-initiation complex (OC-PIC) · an experimental structure of the same protein · chain A against O, TM-score 0.80
- 6EU1 · RNA Polymerase III - open DNA complex (OC-POL3). · an experimental structure of the same protein · chain A against O, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32349
- Elsewhere: UniProt P32349 · AlphaFold DB P32349
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