MolNFT v1 · #379687 · protein
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF125 (Q96EQ8)
Q96EQ8: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF125 (Q96EQ8)”. 4 pockets (best druggability 0.57). MolNFT v1 #379687 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q96EQ8
- Type
- protein
- Length
- 232 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf4ED13986579E8e227b3ED6c02276c648754EC27
- Molecule
- E3 ubiquitin-protein ligase RNF125
- UniProt
- Q96EQ8
- Pockets
- 4 · best druggability 0.57
Structure
1 distinct chain · 32% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase RNF125 | protein | 232 | 32% helix, 10% strand | Q96EQ8 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 324 | 0.57 | 0.76 | 30 | empty |
| 2 | 77 | 0.41 | 0.79 | 14 | empty |
| 3 | 55 | 0.32 | 0.77 | 14 | empty |
| 4 | 59 | 0.31 | 0.75 | 17 | empty |
Compared structures
- 5DKA · A C2HC zinc finger is essential for the activity of the RING ubiquitin ligase RNF125 · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 5DKA · A C2HC zinc finger is essential for the activity of the ring ubiquitin ligase RNF125 · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 8GCB · Structure of RNF125 in complex with a UbcH5b~Ub conjugate · an experimental structure of the same protein · chain A against B, TM-score 0.39
- 8GBQ · Structure of RNF125 in complex with UbcH5b · an experimental structure of the same protein · chain A against B, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96EQ8
- Elsewhere: UniProt Q96EQ8 · AlphaFold DB Q96EQ8
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