UniProt Q96EQ8
E3 ubiquitin-protein ligase RNF125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (UniProt Q96EQ8), EC 2.3.2.27: 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q96EQ8
- Protein
- E3 ubiquitin-protein ligase RNF125
- EC
- 2.3.2.27
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 2 records with a druggable one
Structures
5 records of Q96EQ8 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5DKA | A C2HC zinc finger is essential for the activity of the RING ubiquitin ligase RNF125 | x-ray diffraction | A, B | ZN, CL, MG | — |
| 5DKA | A C2HC zinc finger is essential for the activity of the ring ubiquitin ligase RNF125 | x-ray diffraction | A, B | — | — |
| 8GBQ | Structure of RNF125 in complex with UbcH5b | x-ray diffraction | B | ZN | 3 (best 0.51) |
| 8GCB | Structure of RNF125 in complex with a UbcH5b~Ub conjugate | x-ray diffraction | B | ZN | 3 (best 0.46) |
| Q96EQ8 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF125 (Q96EQ8) | predicted | A | — | 4 (best 0.57) |
Ligands
Experiment against prediction
- 5DKA chain A against the predicted model Q96EQ8: TM-score 0.95, RMSD 0.91 Å
- 5DKA chain A against the predicted model Q96EQ8: TM-score 0.95, RMSD 0.91 Å
- 8GCB chain B against the predicted model Q96EQ8: TM-score 0.94, RMSD 0.96 Å
- 8GBQ chain B against the predicted model Q96EQ8: TM-score 0.93, RMSD 1.00 Å
Elsewhere
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