MolNFT v1 · #333972 · protein

AlphaFold monomer V2.0 prediction for retinoblastoma-like protein 2 (Q08999)

Q08999: “AlphaFold monomer V2.0 prediction for retinoblastoma-like protein 2 (Q08999)”. 17 pockets (best druggability 0.79). MolNFT v1 #333972 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q08999
Type: protein
Length: 1,139 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x3298b100681D3A2372Bba3b2f282750dD71629B9
Molecule: Retinoblastoma-like protein 2
UniProt: Q08999
Pockets: 17 · best druggability 0.79

Structure

1 distinct chain · 45% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Retinoblastoma-like protein 2	protein	1139	45% helix, 4% strand	Q08999

Pockets

17 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	668	0.79	0.84	77	empty
2	850	0.72	0.76	49	empty
3	215	0.68	0.85	33	empty
4	204	0.53	0.77	26	empty
5	117	0.50	0.80	21	empty

Compared structures

4XI9 · Human ogt in complex with udp-5S-glcnac and substrate peptide (RBL2) · an experimental structure of the same protein · chain A against E, TM-score 0.01
4XI9 · Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RBL2) · an experimental structure of the same protein · chain A against E, TM-score 0.01
5C1D · Human ogt in complex with udp-5S-glcnac and substrate peptide (RB2L) · an experimental structure of the same protein · chain A against C, TM-score 0.01

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08999
Elsewhere: UniProt Q08999 · AlphaFold DB Q08999

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