UniProt Q08999
Retinoblastoma-like protein 2 (Q08999)
Retinoblastoma-like protein 2 (UniProt Q08999): 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q08999
- Protein
- Retinoblastoma-like protein 2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 27 · 3 records with a druggable one
Structures
5 records of Q08999 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XI9 | Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RBL2) | x-ray diffraction | E, F, G, H | 12V | 7 (best 0.82) |
| 4XI9 | Human ogt in complex with udp-5S-glcnac and substrate peptide (RBL2) | x-ray diffraction | E, F, G, H | — | — |
| 5C1D | Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RB2L) | x-ray diffraction | C | 12V | 3 (best 0.77) |
| 5C1D | Human ogt in complex with udp-5S-glcnac and substrate peptide (RB2L) | x-ray diffraction | C | — | — |
| Q08999 | AlphaFold monomer V2.0 prediction for retinoblastoma-like protein 2 (Q08999) | predicted | A | — | 17 (best 0.79) |
Ligands
- 12V · (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S, 4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3, 4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate · in 2 records
Experiment against prediction
- 4XI9 chain E against the predicted model Q08999: TM-score 0.58, RMSD 0.80 Å
- 4XI9 chain E against the predicted model Q08999: TM-score 0.58, RMSD 0.80 Å
- 4XI9 chain H against the predicted model Q08999: TM-score 0.55, RMSD 0.96 Å
- 4XI9 chain F against the predicted model Q08999: TM-score 0.54, RMSD 0.86 Å
- 5C1D chain C against the predicted model Q08999: TM-score 0.45, RMSD 1.35 Å
- 5C1D chain C against the predicted model Q08999: TM-score 0.45, RMSD 1.35 Å
- 4XI9 chain G against the predicted model Q08999: TM-score 0.44, RMSD 1.42 Å
Elsewhere
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