MolNFT v1 · #332221 · protein
AlphaFold monomer V2.0 prediction for rab proteins geranylgeranyltransferase component a 1 (P37727)
P37727: “AlphaFold monomer V2.0 prediction for rab proteins geranylgeranyltransferase component a 1 (P37727)”. 7 pockets (best druggability 0.68). MolNFT v1 #332221 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P37727
- Type
- protein
- Length
- 650 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x738906Bd2e852C8F7c11851E854a1a2e1bf76Ede
- Molecule
- Rab proteins geranylgeranyltransferase component a 1
- UniProt
- P37727
- Pockets
- 7 · best druggability 0.68
Structure
1 distinct chain · 26% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rab proteins geranylgeranyltransferase component a 1 | protein | 650 | 26% helix, 20% strand | P37727 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 489 | 0.68 | 0.79 | 45 | empty |
| 2 | 251 | 0.56 | 0.78 | 44 | empty |
| 3 | 96 | 0.52 | 0.83 | 18 | empty |
| 4 | 242 | 0.52 | 0.76 | 31 | empty |
| 5 | 101 | 0.40 | 0.77 | 17 | empty |
Compared structures
- 1VG9 · The crystal structures of the rep-1 protein in complex with C- terminally truncated RAB7… · an experimental structure of the same protein · chain A against C, TM-score 0.77
- 1VG9 · The crystal structures of the REP-1 protein in complex with C-terminally truncated Rab7… · an experimental structure of the same protein · chain A against C, TM-score 0.77
- 1LTX · Structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and… · an experimental structure of the same protein · chain A against R, TM-score 0.74
- 1LTX · Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and… · an experimental structure of the same protein · chain A against R, TM-score 0.74
- 1VG0 · The crystal structures of the rep-1 protein in complex with monoprenylated RAB7 protein · an experimental structure of the same protein · chain A against A, TM-score 0.74
- 1VG0 · The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein · an experimental structure of the same protein · chain A against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37727
- Elsewhere: UniProt P37727 · AlphaFold DB P37727
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