MolNFT v1 · #331953 · protein
AlphaFold monomer V2.0 prediction for DNA repair protein RAD4 (P14736)
P14736: “AlphaFold monomer V2.0 prediction for DNA repair protein RAD4 (P14736)”. 6 pockets (best druggability 0.72). MolNFT v1 #331953 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P14736
- Type
- protein
- Length
- 754 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xD8181c44e77460dc4278886267608d4Cf45E86B0
- Molecule
- DNA repair protein RAD4
- UniProt
- P14736
- Pockets
- 6 · best druggability 0.72
Structure
1 distinct chain · 35% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA repair protein RAD4 | protein | 754 | 35% helix, 14% strand | P14736 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 870 | 0.72 | 0.77 | 70 | empty |
| 2 | 495 | 0.58 | 0.73 | 46 | empty |
| 3 | 340 | 0.56 | 0.75 | 36 | empty |
| 4 | 267 | 0.51 | 0.75 | 23 | empty |
| 5 | 54 | 0.35 | 0.79 | 14 | empty |
Compared structures
- 2QSH · Crystal structure of Rad4-Rad23 bound to a mismatch DNA · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 2QSH · Crystal structure of RAD4-RAD23 bound to a mismatch DNA · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 2QSG · Crystal structure of Rad4-Rad23 bound to a UV-damaged DNA · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 2QSG · Crystal structure of RAD4-RAD23 bound to a UV-damaged DNA · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 4YIR · Crystal structure of RAD4-RAD23 crosslinked to an undamaged DNA · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 4YIR · Crystal structure of Rad4-Rad23 crosslinked to an undamaged DNA · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 6CFI · Crystal structure of RAD4-RAD23 bound to a 6-4 photoproduct UV lesion · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 6CFI · Crystal structure of Rad4-Rad23 bound to a 6-4 photoproduct UV lesion · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 7K04 · Structure of TFIIH/Rad4-Rad23-Rad33/DNA in DNA opening · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 7K04 · Structure of TFIIH/RAD4-RAD23-RAD33/DNA in DNA opening · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 6UBF · Role of beta-hairpin motifs in the DNA duplex opening by the RAD4/XPC nucleotide excision… · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 6UBF · Role of Beta-hairpin motifs in the DNA duplex opening by the Rad4/XPC nucleotide excision… · an experimental structure of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14736
- Elsewhere: UniProt P14736 · AlphaFold DB P14736
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