MolNFT v1 · #331929 · protein
AlphaFold monomer V2.0 prediction for checkpoint protein RAD24 (P32641)
P32641: “AlphaFold monomer V2.0 prediction for checkpoint protein RAD24 (P32641)”. 9 pockets (best druggability 0.79). MolNFT v1 #331929 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P32641
- Type
- protein
- Length
- 659 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xC0491A7e4a5851164cEffD648c5067B32B6C2422
- Molecule
- Checkpoint protein RAD24
- UniProt
- P32641
- Pockets
- 9 · best druggability 0.79
Structure
1 distinct chain · 49% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Checkpoint protein RAD24 | protein | 659 | 49% helix, 5% strand | P32641 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 820 | 0.79 | 0.82 | 91 | empty |
| 2 | 593 | 0.73 | 0.80 | 55 | empty |
| 3 | 202 | 0.55 | 0.79 | 29 | empty |
| 4 | 91 | 0.52 | 0.84 | 22 | empty |
| 5 | 86 | 0.45 | 0.80 | 15 | empty |
Compared structures
- 7ST9 · Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 7ST9 · Open state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 7STB · Closed state of RAD24-RFC:9-1-1 bound to a 5' SS/DSDNA junction · an experimental structure of the same protein · chain A against A, TM-score 0.58
- 7STB · Closed state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction · an experimental structure of the same protein · chain A against A, TM-score 0.58
- 8FS6 · Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in… · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 8FS5 · Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in… · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 8FS3 · Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in… · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 8FS7 · Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in… · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 8FS4 · Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in… · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 8FS8 · Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 5-nt gapped DNA… · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 7SGZ · Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 7SGZ · Structure of the yeast RAD24-rfc loader bound to DNA and the closed 9- 1-1 clamp · an experimental structure of the same protein · chain A against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32641
- Elsewhere: UniProt P32641 · AlphaFold DB P32641
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