MolNFT v1 · #319883 · protein

AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase U (Q92729)

Q92729: “AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase U (Q92729)”. 11 pockets (best druggability 0.77). MolNFT v1 #319883 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q92729
Type: protein
Length: 1,446 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x4d07E6a23DeB6B95bd9b90EcB67368b7e8D3B77e
Molecule: Receptor-type tyrosine-protein phosphatase U
UniProt: Q92729
Pockets: 11 · best druggability 0.77

Structure

1 distinct chain · 19% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase U	protein	1446	19% helix, 32% strand	Q92729

Pockets

11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	957	0.77	0.79	94	empty
2	544	0.67	0.77	47	empty
3	149	0.57	0.82	28	empty
4	219	0.50	0.75	31	empty
5	189	0.45	0.74	24	empty

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

6SUB · Human ptpru D1 domain, reduced form · an experimental structure of the same protein · chain A against A, TM-score 0.17
6SUC · Human ptpru D1 domain, oxidised form · an experimental structure of the same protein · chain A against A, TM-score 0.16

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92729
Elsewhere: UniProt Q92729 · AlphaFold DB Q92729

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