MolNFT v1 · #308492 · protein
AlphaFold monomer V2.0 prediction for DNA primase large subunit (P49643)
P49643: “AlphaFold monomer V2.0 prediction for DNA primase large subunit (P49643)”. 12 pockets (best druggability 0.72). MolNFT v1 #308492 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P49643
- Type
- protein
- Length
- 509 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7a1388B6Aad67B04634A32f63b8A6D6005eab86c
- Molecule
- DNA primase large subunit
- UniProt
- P49643
- Pockets
- 12 · best druggability 0.72
Structure
1 distinct chain · 57% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA primase large subunit | protein | 509 | 57% helix, 3% strand | P49643 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 573 | 0.72 | 0.80 | 64 | empty |
| 2 | 91 | 0.65 | 0.90 | 19 | empty |
| 3 | 191 | 0.51 | 0.77 | 19 | empty |
| 4 | 139 | 0.43 | 0.76 | 21 | empty |
| 5 | 112 | 0.39 | 0.74 | 16 | empty |
Compared structures
- 8QJ7 · Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1 · an experimental structure of the same protein · chain A against D, TM-score 0.82
- 7OPL · Cryoem structure of DNA polymerase alpha - primase bound to SARS cov NSP1 · an experimental structure of the same protein · chain A against D, TM-score 0.82
- 5EXR · Crystal structure of human primosome · an experimental structure of the same protein · chain A against B, TM-score 0.81
- 5EXR · Crystal structure of human primosome · an experimental structure of the same protein · chain A against B, TM-score 0.81
- 9C8V · Human DNA polymerase alpha/primase - CHAPSO (4 mM) · an experimental structure of the same protein · chain A against B, TM-score 0.81
- 7U5C · Cryo-EM structure of human cst bound to DNA polymerase alpha-primase in a recruitment… · an experimental structure of the same protein · chain A against B, TM-score 0.80
- 7U5C · Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment… · an experimental structure of the same protein · chain A against B, TM-score 0.80
- 4RR2 · Crystal structure of human primase · an experimental structure of the same protein · chain A against D, TM-score 0.54
- 4RR2 · Crystal structure of human primase · an experimental structure of the same protein · chain A against D, TM-score 0.54
- 8D9D · Human DNA polymerase-alpha/primase elongation complex II bound to primer/template · an experimental structure of the same protein · chain A against B, TM-score 0.51
- 8D0K · Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback… · an experimental structure of the same protein · chain A against E, TM-score 0.45
- 8D0B · Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback… · an experimental structure of the same protein · chain A against E, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49643
- Elsewhere: UniProt P49643 · AlphaFold DB P49643
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