UniProt P49643
DNA primase large subunit (P49643)
DNA primase large subunit (UniProt P49643), EC 2.7.7.-: 31 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49643
- Protein
- DNA primase large subunit
- EC
- 2.7.7.-
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 46 · 7 records with a druggable one
Structures
32 records of P49643 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3L9Q | Crystal structure of human polymerase alpha-primase p58 iron-sulfur cluster domain | x-ray diffraction | A, B | — | — |
| 3L9Q | Crystal structure of human polymerase alpha-primase P58 iron-sulfur cluster domain | x-ray diffraction | A, B | — | — |
| 3Q36 | Crystal structure of the 4Fe-4S cluster domain of human DNA primase large subunit | x-ray diffraction | A, B | — | — |
| 3Q36 | Crystal structure of the 4FE-4S cluster domain of human DNA primase large subunit | x-ray diffraction | A, B | — | — |
| 4BPU | Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL… | x-ray diffraction | B, D | — | — |
| 4BPU | Crystal structure of human primase in heterodimeric form, comprising pris and truncated pril… | x-ray diffraction | B, D | — | — |
| 4BPW | Crystal structure of human primase bound to UTP | x-ray diffraction | B, D | — | — |
| 4BPW | Crystal structure of human primase bound to UTP | x-ray diffraction | B, D | — | — |
| 4BPX | Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase… | x-ray diffraction | B, D | — | — |
| 4BPX | Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase… | x-ray diffraction | B, D | — | — |
| 4RR2 | Crystal structure of human primase | x-ray diffraction | B, D | — | — |
| 4RR2 | Crystal structure of human primase | x-ray diffraction | B, D | — | — |
| 5DQO | Crystal structure of Y347F mutant of human primase p58 iron-sulfur cluster domain | x-ray diffraction | A, B, C, D | SF4 | — |
| 5DQO | Crystal structure of Y347F mutant of human primase P58 iron-sulfur cluster domain | x-ray diffraction | A, B, C, D | — | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | B, F | SF4 | — |
| 5EXR | Crystal structure of human primosome | x-ray diffraction | B, F | — | — |
| 5F0Q | Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA… | x-ray diffraction | A, B | — | — |
| 5F0S | Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA… | x-ray diffraction | A, B | SF4, MN | — |
| 5F0S | Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA… | x-ray diffraction | A, B | — | — |
| 5I7M | Crystal structure of Y345F mutant of human primase P58 iron-sulfur cluster domain | x-ray diffraction | A, B | — | — |
| 6DHW | Crystal structure of primase iron-sulfur domain (266-457) | x-ray diffraction | A, B | SF4, SO4 | 6 (best 0.67) |
| 6DHW | Crystal structure of primase iron-sulfur domain (266-457) | x-ray diffraction | A, B | SF4, SO4 | — |
| 7OPL | Cryoem structure of DNA polymerase alpha - primase bound to SARS cov NSP1 | electron microscopy | D | SF4 | — |
| 7U5C | Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | B | SF4 | 7 (best 0.82) |
| 7U5C | Cryo-EM structure of human cst bound to DNA polymerase alpha-primase in a recruitment state | electron microscopy | B | SF4 | — |
| 8D0B | Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template | electron microscopy | E | — | 2 (best 0.73) |
| 8D0B | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template | electron microscopy | E | — | — |
| 8D0K | Human cst-DNA polymerase ALPHA/PRIMASE preinitiation complex bound to 4XTEL-foldback template… | electron microscopy | E | — | — |
| 8D9D | Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | electron microscopy | B | SF4 | 7 (best 0.81) |
| 8QJ7 | Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1 | electron microscopy | D | SF4 | 5 (best 0.86) |
| 9C8V | Human DNA polymerase alpha/primase - CHAPSO (4 mM) | electron microscopy | B | SF4 | 7 (best 0.87) |
| P49643 | AlphaFold monomer V2.0 prediction for DNA primase large subunit (P49643) | predicted | A | — | 12 (best 0.72) |
Ligands
Experiment against prediction
- 3Q36 chain A against the predicted model P49643: TM-score 0.99, RMSD 0.51 Å
- 3Q36 chain A against the predicted model P49643: TM-score 0.99, RMSD 0.51 Å
- 5F0Q chain B against the predicted model P49643: TM-score 0.99, RMSD 0.55 Å
- 5F0S chain B against the predicted model P49643: TM-score 0.99, RMSD 0.56 Å
- 5F0S chain B against the predicted model P49643: TM-score 0.99, RMSD 0.56 Å
- 5F0Q chain A against the predicted model P49643: TM-score 0.99, RMSD 0.58 Å
- 5F0S chain A against the predicted model P49643: TM-score 0.99, RMSD 0.59 Å
- 5F0S chain A against the predicted model P49643: TM-score 0.99, RMSD 0.59 Å
- 3Q36 chain B against the predicted model P49643: TM-score 0.99, RMSD 0.67 Å
- 3Q36 chain B against the predicted model P49643: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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