AlphaFold monomer V2.0 prediction for lysosomal protective protein (P10619)

Structure

1 distinct chain · 34% helix, 22% strand (DSSP).

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

• 1IVY · Physiological dimer hpp precursor · an experimental structure of the same protein · chain A against A, TM-score 0.94
• 1IVY · Physiological dimer hpp precursor · an experimental structure of the same protein · chain A against A, TM-score 0.94
• 4CI9 · Crystal structure of cathepsin a, apo-structure · an experimental structure of the same protein · chain A against A, TM-score 0.86
• 4CI9 · Crystal structure of cathepsin A, apo-structure · an experimental structure of the same protein · chain A against A, TM-score 0.86
• 4MWT · Crystal structure of human PPCA (trigonal crystal form 2) · an experimental structure of the same protein · chain A against A, TM-score 0.86
• 4MWT · Crystal structure of human ppca (trigonal crystal form 2) · an experimental structure of the same protein · chain A against A, TM-score 0.86
• 4MWS · Crystal structure of human PPCA (trigonal crystal form 1) · an experimental structure of the same protein · chain A against A, TM-score 0.86
• 4MWS · Crystal structure of human ppca (trigonal crystal form 1) · an experimental structure of the same protein · chain A against A, TM-score 0.86
• 4CIA · Crystal structure of cathepsin A, complexed with compound 1 · an experimental structure of the same protein · chain A against A, TM-score 0.85
• 4CIA · Crystal structure of cathepsin a, complexed with compound 1 · an experimental structure of the same protein · chain A against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P10619
• Elsewhere: UniProt P10619 · AlphaFold DB P10619