MolNFT v1 · #300343 · protein
AlphaFold monomer V2.0 prediction for piwi protein AF_1318 (O28951)
O28951: “AlphaFold monomer V2.0 prediction for piwi protein AF_1318 (O28951)”. 7 pockets (best druggability 0.57). MolNFT v1 #300343 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O28951
- Type
- protein
- Length
- 427 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB35df660264f41795De49C83276C108A4ba91ADE
- Molecule
- Piwi protein AF_1318
- UniProt
- O28951
- Pockets
- 7 · best druggability 0.57
Structure
1 distinct chain · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Piwi protein AF_1318 | protein | 427 | 37% helix, 23% strand | O28951 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.57 | 0.76 | 32 | empty |
| 2 | 219 | 0.55 | 0.78 | 29 | empty |
| 3 | 90 | 0.48 | 0.81 | 19 | empty |
| 4 | 110 | 0.42 | 0.77 | 19 | empty |
| 5 | 75 | 0.36 | 0.77 | 21 | empty |
Compared structures
- 8OK9 · Heterodimeric complex of Archaeoglobus fulgidus Argonaute protein Af1318 (AfAgo) with DNA… · an experimental structure of the same protein · chain A against A, TM-score 0.96
- 1YTU · Structural basis for 5'-end-specific recognition of the guide RNA strand by the a.… · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 1YTU · Structural basis for 5'-end-specific recognition of the guide RNA strand by the A.… · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 6TUO · Crystal structure of archaeoglobus fulgidus argonaute protein with cognate DNA… · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 6T5T · Crystal structure of archaeoglobus fulgidus argonaute protein with cognate DNA… · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 2BGG · The structure of a Piwi protein from Archaeoglobus fulgidus complexed with a 16nt siRNA… · an experimental structure of the same protein · chain A against B, TM-score 0.90
- 2BGG · The structure of a piwi protein from archaeoglobus fulgidus complexed with a 16NT siRNA… · an experimental structure of the same protein · chain A against B, TM-score 0.90
- 1W9H · The structure of a piwi protein from archaeoglobus fulgidus. · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 1W9H · The Structure of a Piwi protein from Archaeoglobus fulgidus. · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 2W42 · The structure of a piwi protein from archaeoglobus fulgidus complexed with a 16NT DNA… · an experimental structure of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O28951
- Elsewhere: UniProt O28951 · AlphaFold DB O28951
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