AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase pim-1 (P11309)

Structure

1 distinct chain · 36% helix, 20% strand (DSSP).

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4K18 · Structure of PIM-1 kinase bound to 5-(4-cyanobenzyl)-N-(4-fluorophenyl)-7-hydroxypyrazolo[… · an experimental structure of the same protein · chain A against A, TM-score 0.88
• 3F2A · Crystal structure of human Pim-1 in complex with DAPPA · an experimental structure of the same protein · chain A against A, TM-score 0.88
• 1XQZ · Crystal Structure of hPim-1 kinase at 2.1 A resolution · an experimental structure of the same protein · chain A against A, TM-score 0.88
• 4N70 · Pim1 Complexed with a pyridylcarboxamide · an experimental structure of the same protein · chain A against A, TM-score 0.88
• 2BZH · Crystal structure of the human PIM1 in complex with a ruthenium organometallic ligand RU1 · an experimental structure of the same protein · chain A against B, TM-score 0.87
• 2OI4 · Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole · an experimental structure of the same protein · chain A against X, TM-score 0.87
• 1XR1 · Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 4K0Y · Structure of PIM-1 kinase bound to N-(4-fluorophenyl)-7-hydroxy-5-(piperidin-4-yl)pyrazolo… · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 4JX7 · Crystal structure of Pim1 kinase in complex with inhibitor… · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 3QF9 · Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with… · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 4JX3 · Crystal structure of Pim1 kinase · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 4N6Y · Pim1 Complexed with a phenylcarboxamide · an experimental structure of the same protein · chain A against A, TM-score 0.87

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P11309
• Elsewhere: UniProt P11309 · AlphaFold DB P11309