MolNFT v1 · #299210 · protein

AlphaFold monomer V2.0 prediction for phosphoinositide 3-kinase regulatory subunit 4 (Q99570)

Q99570: “AlphaFold monomer V2.0 prediction for phosphoinositide 3-kinase regulatory subunit 4 (Q99570)”. 15 pockets (best druggability 0.84). MolNFT v1 #299210 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q99570
Type: protein
Length: 1,358 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x7FDF8b382C6a36A8772D1A265E8e480c7DF0A9C1
Molecule: Phosphoinositide 3-kinase regulatory subunit 4
UniProt: Q99570
Pockets: 15 · best druggability 0.84

Structure

1 distinct chain · 39% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoinositide 3-kinase regulatory subunit 4	protein	1358	39% helix, 18% strand	Q99570

Pockets

15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	673	0.84	0.88	50	empty
2	885	0.73	0.77	70	empty
3	304	0.69	0.83	35	empty
4	551	0.67	0.77	43	empty
5	329	0.63	0.79	27	empty

Compared structures

8SOR · Structure of human PI3KC3-C1 complex · an experimental structure of the same protein · chain A against A, TM-score 0.56
7BL1 · human complex II-BATS bound to membrane-attached Rab5a-GTP · an experimental structure of the same protein · chain A against CCC, TM-score 0.50
9C82 · Structure of human ULK1C:PI3KC3-C1 supercomplex · an experimental structure of the same protein · chain A against A, TM-score 0.48

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99570
Elsewhere: UniProt Q99570 · AlphaFold DB Q99570

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