UniProt Q99570
Phosphoinositide 3-kinase regulatory subunit 4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (UniProt Q99570), EC 2.7.11.1: 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 64 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q99570
- Protein
- Phosphoinositide 3-kinase regulatory subunit 4
- EC
- 2.7.11.1
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 64 · 4 records with a druggable one
Structures
4 records of Q99570 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7BL1 | human complex II-BATS bound to membrane-attached Rab5a-GTP | electron microscopy | CCC | — | 15 (best 0.79) |
| 8SOR | Structure of human PI3KC3-C1 complex | electron microscopy | A | ADP | 19 (best 0.82) |
| 9C82 | Structure of human ULK1C:PI3KC3-C1 supercomplex | electron microscopy | A | — | 15 (best 0.83) |
| Q99570 | AlphaFold monomer V2.0 prediction for phosphoinositide 3-kinase regulatory subunit 4 (Q99570) | predicted | A | — | 15 (best 0.84) |
Ligands
- ADP · Adenosine-5'-diphosphate · in 1 record
Experiment against prediction
- 8SOR chain A against the predicted model Q99570: TM-score 0.65, RMSD 2.81 Å
- 9C82 chain A against the predicted model Q99570: TM-score 0.62, RMSD 3.41 Å
- 7BL1 chain CCC against the predicted model Q99570: TM-score 0.57, RMSD 4.95 Å
Elsewhere
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