MolNFT v1 · #294151 · protein
AlphaFold monomer V2.0 prediction for myeloperoxidase (P05164)
P05164: “AlphaFold monomer V2.0 prediction for myeloperoxidase (P05164)”. 9 pockets (best druggability 0.86). MolNFT v1 #294151 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P05164
- Type
- protein
- Length
- 745 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x025f3b1a898b05AD2731bE6Ab72687b5920c4A3F
- Molecule
- Myeloperoxidase
- UniProt
- P05164
- Pockets
- 9 · best druggability 0.86
Structure
1 distinct chain · 43% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myeloperoxidase | protein | 745 | 43% helix, 8% strand | P05164 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.86 | 0.96 | 54 | empty |
| 2 | 229 | 0.71 | 0.87 | 34 | empty |
| 3 | 139 | 0.63 | 0.86 | 26 | empty |
| 4 | 158 | 0.50 | 0.78 | 20 | empty |
| 5 | 70 | 0.48 | 0.84 | 19 | empty |
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 5MFA · Crystal structure of human promyeloperoxidase (proMPO) · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 5MFA · Crystal structure of human promyeloperoxidase (prompo) · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 5UZU · Immune evasion by a Staphylococcal Peroxidase Inhibitor that blocks myeloperoxidase · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 5UZU · Immune evasion by a staphylococcal peroxidase inhibitor that blocks myeloperoxidase · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 6AZP · A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase… · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 6AZP · A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase… · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 6BMT · Crystal Structure of a Recombinant form of Human Myeloperoxidase Bound to an Inhibitor… · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 6BMT · Crystal structure of a recombinant form of human myeloperoxidase bound to an inhibitor… · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 7OIH · Glycosylation in the crystal structure of neutrophil myeloperoxidase · an experimental structure of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05164
- Elsewhere: UniProt P05164 · AlphaFold DB P05164
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