MolNFT v1 · #288554 · protein
AlphaFold monomer V2.0 prediction for poly [ADP-ribose] polymerase 2 (O88554)
O88554: “AlphaFold monomer V2.0 prediction for poly [ADP-ribose] polymerase 2 (O88554)”. 6 pockets (best druggability 0.76). MolNFT v1 #288554 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O88554
- Type
- protein
- Length
- 559 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xdf27c3fD9945ab234E04271Bf23AcF50Ec8f9f0E
- Molecule
- Poly [ADP-ribose] polymerase 2
- UniProt
- O88554
- Pockets
- 6 · best druggability 0.76
Structure
1 distinct chain · 28% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Poly [ADP-ribose] polymerase 2 | protein | 559 | 28% helix, 23% strand | O88554 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 597 | 0.76 | 0.82 | 53 | empty |
| 2 | 820 | 0.74 | 0.79 | 72 | empty |
| 3 | 240 | 0.54 | 0.77 | 26 | empty |
| 4 | 81 | 0.35 | 0.76 | 14 | empty |
| 5 | 66 | 0.31 | 0.74 | 16 | empty |
Compared structures
- 1GS0 · Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 1GS0 · Crystal structure of the catalytic fragment of murine poly (ADP-ribose) polymerase-2 · an experimental structure of the same protein · chain A against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O88554
- Elsewhere: UniProt O88554 · AlphaFold DB O88554
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