MolNFT v1 · #288497 · protein
AlphaFold monomer V2.0 prediction for POLY(ADP-ribose) glycohydrolase (O46043)
O46043: “AlphaFold monomer V2.0 prediction for POLY(ADP-ribose) glycohydrolase (O46043)”. 11 pockets (best druggability 0.76). MolNFT v1 #288497 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O46043
- Type
- protein
- Length
- 723 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x29894F62A9f25abd629a1bF7686E1c61F21B176f
- Molecule
- POLY(ADP-ribose) glycohydrolase
- UniProt
- O46043
- Pockets
- 11 · best druggability 0.76
Structure
1 distinct chain · 33% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | POLY(ADP-ribose) glycohydrolase | protein | 723 | 33% helix, 11% strand | O46043 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.76 | 0.88 | 46 | empty |
| 2 | 89 | 0.74 | 0.96 | 32 | empty |
| 3 | 623 | 0.70 | 0.78 | 53 | empty |
| 4 | 58 | 0.67 | 0.95 | 17 | empty |
| 5 | 324 | 0.59 | 0.77 | 40 | empty |
Compared structures
- 8ADK · Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster · an experimental structure of the same protein · chain A against B, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O46043
- Elsewhere: UniProt O46043 · AlphaFold DB O46043
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