UniProt O46043

Poly(ADP-ribose) glycohydrolase (O46043)

Poly(ADP-ribose) glycohydrolase (UniProt O46043), EC 3.2.1.143: 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: O46043
Protein: Poly(ADP-ribose) glycohydrolase
EC: 3.2.1.143
Experimental structures: 2
Predicted models: 1
Ligands: 3
Pockets: 45 · 3 records with a druggable one

Structures

3 records of O46043 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
8ADJ	Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster in complex with PARG inhibitor…	x-ray diffraction	A, B, C	LQX, SO4, CL	20 (best 0.85)
8ADK	Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster	x-ray diffraction	A, B, C	SO4, CL	14 (best 0.84)
O46043	AlphaFold monomer V2.0 prediction for POLY(ADP-ribose) glycohydrolase (O46043)	predicted	A	—	11 (best 0.76)

Ligands

CL · Chloride ion · in 2 records
SO4 · Sulfate ion · in 2 records
LQX · 1-[(2,5-dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide · in 1 record

Experiment against prediction

8ADJ chain B against the predicted model O46043: TM-score 0.99, RMSD 0.76 Å
8ADK chain B against the predicted model O46043: TM-score 0.99, RMSD 0.78 Å
8ADJ chain A against the predicted model O46043: TM-score 0.99, RMSD 0.81 Å
8ADK chain A against the predicted model O46043: TM-score 0.99, RMSD 0.84 Å
8ADJ chain C against the predicted model O46043: TM-score 0.99, RMSD 0.98 Å
8ADK chain C against the predicted model O46043: TM-score 0.99, RMSD 1.01 Å

Elsewhere

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