MolNFT v1 · #288220 · protein

AlphaFold monomer V2.0 prediction for POLY(A) RNA polymerase, mitochondrial (Q9NVV4)

Q9NVV4: “AlphaFold monomer V2.0 prediction for POLY(A) RNA polymerase, mitochondrial (Q9NVV4)”. 8 pockets (best druggability 0.74). MolNFT v1 #288220 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9NVV4
Type: protein
Length: 582 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xdF2b063d4B94F3f46D117B1af99A846bD4a59284
Molecule: POLY(A) RNA polymerase, mitochondrial
UniProt: Q9NVV4
Pockets: 8 · best druggability 0.74

Structure

1 distinct chain · 37% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	POLY(A) RNA polymerase, mitochondrial	protein	582	37% helix, 13% strand	Q9NVV4

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	992	0.74	0.77	67	empty
2	235	0.66	0.84	30	empty
3	360	0.60	0.76	37	empty
4	272	0.54	0.76	28	empty
5	173	0.52	0.79	17	empty

Compared structures

3PQ1 · Crystal structure of human mitochondrial poly(A) polymerase (PAPD1) · an experimental structure of the same protein · chain A against A, TM-score 0.59
3PQ1 · Crystal structure of human mitochondrial POLY(A) polymerase (PAPD1) · an experimental structure of the same protein · chain A against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NVV4
Elsewhere: UniProt Q9NVV4 · AlphaFold DB Q9NVV4

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