MolNFT v1 · #282558 · protein
AlphaFold monomer V2.0 prediction for origin recognition complex subunit 5 (P50874)
P50874: “AlphaFold monomer V2.0 prediction for origin recognition complex subunit 5 (P50874)”. 4 pockets (best druggability 0.52). MolNFT v1 #282558 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P50874
- Type
- protein
- Length
- 479 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9F605311B7e26e76340423EfAfbE5e2EFc7A0b7C
- Molecule
- Origin recognition complex subunit 5
- UniProt
- P50874
- Pockets
- 4 · best druggability 0.52
Structure
1 distinct chain · 49% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Origin recognition complex subunit 5 | protein | 479 | 49% helix, 8% strand | P50874 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 277 | 0.52 | 0.75 | 33 | empty |
| 2 | 218 | 0.51 | 0.76 | 32 | empty |
| 3 | 77 | 0.33 | 0.75 | 13 | empty |
| 4 | 54 | 0.25 | 0.72 | 12 | empty |
Compared structures
- 7MCA · Structure of the S. cerevisiae origin recognition complex bound to the replication… · an experimental structure of the same protein · chain A against E, TM-score 0.68
- 5ZR1 · Saccharomyces cerevisiae origin recognition complex bound to a 72-bp origin DNA… · an experimental structure of the same protein · chain A against E, TM-score 0.68
- 5V8F · Structural basis of MCM2-7 replicative helicase loading by orc-CDC6 and CDT1 · an experimental structure of the same protein · chain A against E, TM-score 0.68
- 6WGI · Atomic model of the mutant occm (orc-CDC6-CDT1-MCM2-7 with MCM6 whd truncation) loaded on… · an experimental structure of the same protein · chain A against E, TM-score 0.68
- 6WGG · Atomic model of pre-insertion mutant occm-DNA COMPLEX(ORC-CDC6-CDT1- MCM2-7 with MCM6 whd… · an experimental structure of the same protein · chain A against E, TM-score 0.68
- 6WGC · Atomic model of semi-attached mutant occm-DNA complex (orc-CDC6-CDT1- MCM2-7 with MCM6… · an experimental structure of the same protein · chain A against E, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50874
- Elsewhere: UniProt P50874 · AlphaFold DB P50874
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