UniProt P50874
Origin recognition complex subunit 5 (P50874)
Origin recognition complex subunit 5 (UniProt P50874): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P50874
- Protein
- Origin recognition complex subunit 5
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 4 records with a druggable one
Structures
10 records of P50874 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | electron microscopy | E | AGS | 5 (best 0.86) |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by orc-CDC6 and CDT1 | electron microscopy | E | AGS | — |
| 5ZR1 | Saccharomyces cerevisiae origin recognition complex bound to a 72-bp origin DNA containing acs and… | electron microscopy | E | AGS, MG | — |
| 6RQC | Cryo-EM structure of an MCM loading intermediate | electron microscopy | E | ATP, MG | 6 (best 0.90) |
| 6WGC | Atomic model of semi-attached mutant occm-DNA complex (orc-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | E | AGS | — |
| 6WGG | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | electron microscopy | E | AGS | 5 (best 0.88) |
| 6WGG | Atomic model of pre-insertion mutant occm-DNA COMPLEX(ORC-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | E | AGS | — |
| 6WGI | Atomic model of the mutant occm (orc-CDC6-CDT1-MCM2-7 with MCM6 whd truncation) loaded on DNA at… | electron microscopy | E | AGS, MG | — |
| 7MCA | Structure of the S. cerevisiae origin recognition complex bound to the replication initiator CDC6… | electron microscopy | E | MG, AGS | — |
| P50874 | AlphaFold monomer V2.0 prediction for origin recognition complex subunit 5 (P50874) | predicted | A | — | 4 (best 0.52) |
Ligands
Experiment against prediction
- 5V8F chain E against the predicted model P50874: TM-score 0.77, RMSD 3.68 Å
- 5V8F chain E against the predicted model P50874: TM-score 0.77, RMSD 3.68 Å
- 6WGI chain E against the predicted model P50874: TM-score 0.76, RMSD 3.65 Å
- 6WGG chain E against the predicted model P50874: TM-score 0.76, RMSD 3.68 Å
- 6WGG chain E against the predicted model P50874: TM-score 0.76, RMSD 3.68 Å
- 6WGC chain E against the predicted model P50874: TM-score 0.76, RMSD 3.68 Å
- 7MCA chain E against the predicted model P50874: TM-score 0.72, RMSD 4.07 Å
- 5ZR1 chain E against the predicted model P50874: TM-score 0.71, RMSD 3.14 Å
- 6RQC chain E against the predicted model P50874: TM-score 0.70, RMSD 3.40 Å
Elsewhere
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