MolNFT v1 · #282514 · protein
AlphaFold monomer V2.0 prediction for origin recognition complex subunit 1 (P54784)
P54784: “AlphaFold monomer V2.0 prediction for origin recognition complex subunit 1 (P54784)”. 8 pockets (best druggability 0.56). MolNFT v1 #282514 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P54784
- Type
- protein
- Length
- 914 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbDA05C32aD6eE153C8C5A78dfa48d7Ba25694fea
- Molecule
- Origin recognition complex subunit 1
- UniProt
- P54784
- Pockets
- 8 · best druggability 0.56
Structure
1 distinct chain · 36% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Origin recognition complex subunit 1 | protein | 914 | 36% helix, 16% strand | P54784 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 271 | 0.56 | 0.76 | 27 | empty |
| 2 | 137 | 0.48 | 0.79 | 28 | empty |
| 3 | 103 | 0.46 | 0.79 | 17 | empty |
| 4 | 124 | 0.46 | 0.78 | 16 | empty |
| 5 | 108 | 0.45 | 0.78 | 16 | empty |
Compared structures
- 5ZR1 · Saccharomyces cerevisiae origin recognition complex bound to a 72-bp origin DNA… · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 7MCA · Structure of the S. cerevisiae origin recognition complex bound to the replication… · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 7MCA · Structure of the S. cerevisiae origin recognition complex bound to the replication… · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 6RQC · Cryo-EM structure of an MCM loading intermediate · an experimental structure of the same protein · chain A against A, TM-score 0.45
- 5V8F · Structural basis of MCM2-7 replicative helicase loading by orc-CDC6 and CDT1 · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 5V8F · Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 6WGC · Atomic model of semi-attached mutant occm-DNA complex (orc-CDC6-CDT1- MCM2-7 with MCM6… · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 6WGG · Atomic model of pre-insertion mutant occm-DNA COMPLEX(ORC-CDC6-CDT1- MCM2-7 with MCM6 whd… · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 6WGG · Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD… · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 6WGI · Atomic model of the mutant occm (orc-CDC6-CDT1-MCM2-7 with MCM6 whd truncation) loaded on… · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 6WGI · Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on… · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 6OM3 · Crystal structure of the ORC1 bah domain in complex with a nucleosome core particle · an experimental structure of the same protein · chain A against L, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54784
- Elsewhere: UniProt P54784 · AlphaFold DB P54784
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.