UniProt P54784
Origin recognition complex subunit 1 (P54784)
Origin recognition complex subunit 1 (UniProt P54784): 29 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 124 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P54784
- Protein
- Origin recognition complex subunit 1
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 124 · 17 records with a druggable one
Structures
30 records of P54784 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1M4Z | Crystal structure of the N-terminal BAH domain of Orc1p | x-ray diffraction | A, B | — | — |
| 1M4Z | Crystal structure of the N-terminal bah domain of ORC1P | x-ray diffraction | A, B | — | — |
| 1ZBX | Crystal structure of a Orc1p-Sir1p complex | x-ray diffraction | A | — | — |
| 1ZBX | Crystal structure of a ORC1P-SIR1P complex | x-ray diffraction | A | — | — |
| 1ZHI | Complex of the S. cerevisiae Orc1 and Sir1 interacting domains | x-ray diffraction | A | — | — |
| 1ZHI | Complex of the S. cerevisiae ORC1 and SIR1 interacting domains | x-ray diffraction | A | — | — |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | electron microscopy | A | AGS | 7 (best 0.87) |
| 5V8F | Structural basis of MCM2-7 replicative helicase loading by orc-CDC6 and CDT1 | electron microscopy | A | AGS | — |
| 5ZR1 | Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and… | electron microscopy | A | AGS, MG | 7 (best 0.86) |
| 5ZR1 | Saccharomyces cerevisiae origin recognition complex bound to a 72-bp origin DNA containing acs and… | electron microscopy | A | AGS, MG | — |
| 6OM3 | Crystal structure of the Orc1 BAH domain in complex with a nucleosome core particle | x-ray diffraction | K, L, W, X | — | 6 (best 0.73) |
| 6OM3 | Crystal structure of the ORC1 bah domain in complex with a nucleosome core particle | x-ray diffraction | K, L, W, X | ACE | — |
| 6RQC | Cryo-EM structure of an MCM loading intermediate | electron microscopy | A | ATP, MG | 5 (best 0.89) |
| 6WGC | Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD… | electron microscopy | A | AGS | 9 (best 0.87) |
| 6WGC | Atomic model of semi-attached mutant occm-DNA complex (orc-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | A | AGS | — |
| 6WGG | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | electron microscopy | A | AGS | 5 (best 0.88) |
| 6WGG | Atomic model of pre-insertion mutant occm-DNA COMPLEX(ORC-CDC6-CDT1- MCM2-7 with MCM6 whd… | electron microscopy | A | AGS | — |
| 6WGI | Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at… | electron microscopy | A | AGS, MG | 5 (best 0.88) |
| 6WGI | Atomic model of the mutant occm (orc-CDC6-CDT1-MCM2-7 with MCM6 whd truncation) loaded on DNA at… | electron microscopy | A | AGS, MG | — |
| 7E9C | Cryo-EM structure of the 1:1 Orc1 BAH domain in complex with nucleosome | electron microscopy | K | — | 2 (best 0.83) |
| 7E9F | Cryo-EM structure of the 2:1 Orc1 BAH domain in complex with nucleosome | electron microscopy | K, L | — | 6 (best 0.79) |
| 7MCA | Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6… | electron microscopy | A | MG, AGS | 10 (best 0.88) |
| 7MCA | Structure of the S. cerevisiae origin recognition complex bound to the replication initiator CDC6… | electron microscopy | A | MG, AGS | — |
| 7TJF | S. cerevisiae ORC bound to 84 bp ARS1 DNA | electron microscopy | A | ATP, MG | 7 (best 0.88) |
| 7TJH | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with flexible Orc6 N-terminal domain | electron microscopy | A | ATP, MG | 11 (best 0.88) |
| 7TJI | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain | electron microscopy | A | ATP, MG | 10 (best 0.86) |
| 7TJJ | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain | electron microscopy | A | ATP, MG | 10 (best 0.88) |
| 7TJK | S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain | electron microscopy | A | ATP, MG | 11 (best 0.88) |
| 9BCX | Cryo-EM structure of the S. cerevisiae ORC-Cdc6-Mcm2-7-DNA complex with a fully closed Mcm2-Mcm5… | electron microscopy | B | ATP, MG | 5 (best 0.88) |
| P54784 | AlphaFold monomer V2.0 prediction for origin recognition complex subunit 1 (P54784) | predicted | A | — | 8 (best 0.56) |
Ligands
Experiment against prediction
- 6OM3 chain L against the predicted model P54784: TM-score 0.97, RMSD 1.02 Å
- 6OM3 chain L against the predicted model P54784: TM-score 0.97, RMSD 1.02 Å
- 6OM3 chain W against the predicted model P54784: TM-score 0.96, RMSD 1.10 Å
- 6OM3 chain W against the predicted model P54784: TM-score 0.96, RMSD 1.10 Å
- 6OM3 chain K against the predicted model P54784: TM-score 0.96, RMSD 1.06 Å
- 6OM3 chain K against the predicted model P54784: TM-score 0.96, RMSD 1.06 Å
- 1ZHI chain A against the predicted model P54784: TM-score 0.96, RMSD 1.30 Å
- 1ZHI chain A against the predicted model P54784: TM-score 0.96, RMSD 1.30 Å
- 1ZBX chain A against the predicted model P54784: TM-score 0.94, RMSD 1.89 Å
- 1ZBX chain A against the predicted model P54784: TM-score 0.94, RMSD 1.89 Å
Elsewhere
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