MolNFT v1 · #280395 · protein
AlphaFold monomer V2.0 prediction for pyruvate dehydrogenase E1 component (P0AFG9)
P0AFG9: “AlphaFold monomer V2.0 prediction for pyruvate dehydrogenase E1 component (P0AFG9)”. 7 pockets (best druggability 0.70). MolNFT v1 #280395 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P0AFG9
- Type
- protein
- Length
- 887 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x4Ef77Afb5a3D9F41c95Be3227D1CC986CCb61835
- Molecule
- Pyruvate dehydrogenase E1 component
- UniProt
- P0AFG9
- Pockets
- 7 · best druggability 0.70
Structure
1 distinct chain · 45% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pyruvate dehydrogenase E1 component | protein | 887 | 45% helix, 11% strand | P0AFG9 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 369 | 0.70 | 0.82 | 41 | empty |
| 2 | 70 | 0.46 | 0.83 | 16 | empty |
| 3 | 83 | 0.36 | 0.76 | 15 | empty |
| 4 | 51 | 0.34 | 0.79 | 19 | empty |
| 5 | 71 | 0.33 | 0.75 | 13 | empty |
Compared structures
- 3LPL · E. coli pyruvate dehydrogenase complex E1 component E571A mutant · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3LPL · E. COLI pyruvate dehydrogenase complex E1 component E571A mutant · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3LQ4 · E. coli pyruvate dehydrogenase complex E1 E235A mutant with high TDP concentration · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3LQ4 · E. COLI pyruvate dehydrogenase complex E1 E235A mutant with high tdp concentration · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3LQ2 · E. coli pyruvate dehydrogenase complex E1 E235A mutant with low TDP concentration · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3LQ2 · E. COLI pyruvate dehydrogenase complex E1 E235A mutant with low tdp concentration · an experimental structure of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AFG9
- Elsewhere: UniProt P0AFG9 · AlphaFold DB P0AFG9
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