MolNFT v1 · #278999 · protein
AlphaFold monomer V2.0 prediction for 2'-5'-oligoadenylate synthase 1 (Q29599)
Q29599: “AlphaFold monomer V2.0 prediction for 2'-5'-oligoadenylate synthase 1 (Q29599)”. 3 pockets (best druggability 0.58). MolNFT v1 #278999 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q29599
- Type
- protein
- Length
- 349 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x55F166d9F6A3981E60dDA03De65e7EbdD73842e2
- Molecule
- 2'-5'-oligoadenylate synthase 1
- UniProt
- Q29599
- Pockets
- 3 · best druggability 0.58
Structure
1 distinct chain · 49% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2'-5'-oligoadenylate synthase 1 | protein | 349 | 49% helix, 13% strand | Q29599 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 427 | 0.58 | 0.75 | 51 | empty |
| 2 | 119 | 0.52 | 0.81 | 27 | empty |
| 3 | 124 | 0.43 | 0.76 | 18 | empty |
Compared structures
- 4RWQ · Crystal structure of the apo-state of porcine OAS1 · an experimental structure of the same protein · chain A against A, TM-score 0.96
- 4RWQ · Crystal structure of the apo-state of porcine OAS1 · an experimental structure of the same protein · chain A against A, TM-score 0.96
- 1PX5 · Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced… · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 1PX5 · Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced… · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 4RWN · Crystal structure of the pre-reactive state of porcine OAS1 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 4RWN · Crystal structure of the pre-reactive state of porcine OAS1 · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 4RWO · Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the… · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 4RWO · Crystal structure of the porcine OAS1 L149R mutant in complex with dsrna and apcpp in the… · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 4RWP · Crystal structure of porcine OAS1 in complex with dsrna · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 4RWP · Crystal structure of porcine OAS1 in complex with dsRNA · an experimental structure of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q29599
- Elsewhere: UniProt Q29599 · AlphaFold DB Q29599
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