MolNFT v1 · #270250 · protein
AlphaFold monomer V2.0 prediction for neuropilin-1 (O14786)
O14786: “AlphaFold monomer V2.0 prediction for neuropilin-1 (O14786)”. 8 pockets (best druggability 0.69). MolNFT v1 #270250 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O14786
- Type
- protein
- Length
- 923 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf87a97E0A4bB354D834857B14296240B167cbe70
- Molecule
- Neuropilin-1
- UniProt
- O14786
- Pockets
- 8 · best druggability 0.69
Structure
1 distinct chain · 7% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neuropilin-1 | protein | 923 | 7% helix, 36% strand | O14786 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 649 | 0.69 | 0.77 | 58 | empty |
| 2 | 436 | 0.67 | 0.79 | 60 | empty |
| 3 | 518 | 0.66 | 0.77 | 59 | empty |
| 4 | 168 | 0.51 | 0.78 | 24 | empty |
| 5 | 61 | 0.39 | 0.80 | 18 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2QQM · Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1 · an experimental structure of the same protein · chain A against A, TM-score 0.47
- 2QQM · Crystal structure of the A2B1B2 domains from human neuropilin-1 · an experimental structure of the same protein · chain A against A, TM-score 0.47
- 2QQI · Crystal Structure of the b1b2 Domains from Human Neuropilin-1 · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 2QQI · Crystal structure of the B1B2 domains from human neuropilin-1 · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 9EOU · Crystal Structure of the b1b2 domains from Human Neuropilin-1 in complex with a peptide. · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 8C5G · Structure of human Neuropilin-1 b1b2 domains in complex with Chlorotoxin (Leiurus… · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 4DEQ · Structure of the neuropilin-1/VEGF-a complex · an experimental structure of the same protein · chain A against B, TM-score 0.19
- 4DEQ · Structure of the Neuropilin-1/VEGF-A complex · an experimental structure of the same protein · chain A against B, TM-score 0.19
- 5L73 · Mam domain of human neuropilin-1 · an experimental structure of the same protein · chain A against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14786
- Elsewhere: UniProt O14786 · AlphaFold DB O14786
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