MolNFT v1 · #269033 · protein

AlphaFold monomer V2.0 prediction for bile acid receptor (Q62735)

Q62735: “AlphaFold monomer V2.0 prediction for bile acid receptor (Q62735)”. 3 pockets (best druggability 0.80). MolNFT v1 #269033 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q62735
Type: protein
Length: 469 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x13E88C248c9e8FD361F590BE0a618ae231254269
Molecule: Bile acid receptor
UniProt: Q62735
Pockets: 3 · best druggability 0.80

Structure

1 distinct chain · 46% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bile acid receptor	protein	469	46% helix, 2% strand	Q62735

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	237	0.80	0.92	45	empty
2	176	0.46	0.75	22	empty
3	130	0.41	0.74	19	empty

Compared structures

1OSV · Structural basis for bile acid binding and activation of the nuclear receptor fxr · an experimental structure of the same protein · chain A against A, TM-score 0.46
1OSV · Structural basis for bile acid binding and activation of the nuclear receptor fxr · an experimental structure of the same protein · chain A against A, TM-score 0.46
1OT7 · Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR · an experimental structure of the same protein · chain A against A, TM-score 0.46
1OT7 · Structural basis for 3-deoxy-cdca binding and activation of fxr · an experimental structure of the same protein · chain A against A, TM-score 0.46

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62735
Elsewhere: UniProt Q62735 · AlphaFold DB Q62735

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