AlphaFold monomer V2.0 prediction for oxysterols receptor lxr-alpha (Q13133)

Structure

1 distinct chain · 49% helix, 4% strand (DSSP).

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 3IPU · X-ray structure of benzisoxazole urea synthetic agonist bound to the lxr-alpha · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 3IPU · X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha · an experimental structure of the same protein · chain A against A, TM-score 0.52
• 5AVI · Crystal structure of lxralpha in complex with tert-butyl benzoate analog, compound 4 · an experimental structure of the same protein · chain A against A, TM-score 0.50
• 5AVI · Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 4 · an experimental structure of the same protein · chain A against A, TM-score 0.50
• 5HJS · Identification of lxrbeta selective agonists for the treatment of ALZHEIMER'S disease · an experimental structure of the same protein · chain A against A, TM-score 0.50
• 5HJS · Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease · an experimental structure of the same protein · chain A against A, TM-score 0.50
• 3IPS · X-ray structure of benzisoxazole synthetic agonist bound to the lxr- alpha · an experimental structure of the same protein · chain A against B, TM-score 0.50
• 3IPS · X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha · an experimental structure of the same protein · chain A against B, TM-score 0.50

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q13133
• Elsewhere: UniProt Q13133 · AlphaFold DB Q13133