UniProt Q13133
Oxysterols receptor LXR-alpha (Q13133)
Oxysterols receptor LXR-alpha (UniProt Q13133): 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13133
- Protein
- Oxysterols receptor LXR-alpha
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 13 · 3 records with a druggable one
Structures
15 records of Q13133 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UHL | Crystal structure of the LXRalfa-RXRbeta LBD heterodimer | x-ray diffraction | B | — | — |
| 1UHL | Crystal structure of the lxralfa-rxrbeta lbd heterodimer | x-ray diffraction | B | — | — |
| 3IPQ | X-ray structure of GW3965 synthetic agonist bound to the LXR-alpha | x-ray diffraction | A | — | — |
| 3IPQ | X-ray structure of GW3965 synthetic agonist bound to the lxr-alpha | x-ray diffraction | A | — | — |
| 3IPS | X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha | x-ray diffraction | A, B | — | — |
| 3IPS | X-ray structure of benzisoxazole synthetic agonist bound to the lxr- alpha | x-ray diffraction | A, B | — | — |
| 3IPU | X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha | x-ray diffraction | A, B | — | — |
| 3IPU | X-ray structure of benzisoxazole urea synthetic agonist bound to the lxr-alpha | x-ray diffraction | A, B | — | — |
| 5AVI | Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 4 | x-ray diffraction | A, C | 4KM | 4 (best 0.81) |
| 5AVI | Crystal structure of lxralpha in complex with tert-butyl benzoate analog, compound 4 | x-ray diffraction | A, C | — | — |
| 5AVL | Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 32b | x-ray diffraction | A | — | — |
| 5AVL | Crystal structure of lxralpha in complex with tert-butyl benzoate analog, compound 32B | x-ray diffraction | A | — | — |
| 5HJS | Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease | x-ray diffraction | A, B | 668, SO4 | 5 (best 0.81) |
| 5HJS | Identification of lxrbeta selective agonists for the treatment of ALZHEIMER'S disease | x-ray diffraction | A, B | — | — |
| Q13133 | AlphaFold monomer V2.0 prediction for oxysterols receptor lxr-alpha (Q13133) | predicted | A | — | 4 (best 0.84) |
Ligands
Experiment against prediction
- 3IPQ chain A against the predicted model Q13133: TM-score 0.99, RMSD 0.61 Å
- 3IPQ chain A against the predicted model Q13133: TM-score 0.99, RMSD 0.61 Å
- 5HJS chain A against the predicted model Q13133: TM-score 0.99, RMSD 0.71 Å
- 5HJS chain A against the predicted model Q13133: TM-score 0.99, RMSD 0.71 Å
- 3IPS chain A against the predicted model Q13133: TM-score 0.98, RMSD 0.77 Å
- 3IPS chain A against the predicted model Q13133: TM-score 0.98, RMSD 0.77 Å
- 5HJS chain B against the predicted model Q13133: TM-score 0.98, RMSD 0.77 Å
- 3IPS chain B against the predicted model Q13133: TM-score 0.98, RMSD 0.80 Å
- 3IPS chain B against the predicted model Q13133: TM-score 0.98, RMSD 0.80 Å
- 1UHL chain B against the predicted model Q13133: TM-score 0.98, RMSD 0.78 Å
Elsewhere
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