MolNFT v1 · #267275 · protein
AlphaFold monomer V2.0 prediction for probable 28S rRNA (CYTOSINE(4447)-C(5))-methyltransferase (P46087)
P46087: “AlphaFold monomer V2.0 prediction for probable 28S rRNA (CYTOSINE(4447)-C(5))-methyltransferase (P46087)”. 1 pocket (best druggability 0.57). MolNFT v1 #267275 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P46087
- Type
- protein
- Length
- 812 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xE2FAAD9Bd269b0F591a298c8d3F4EEcE83134D70
- Molecule
- Probable 28S rRNA (CYTOSINE(4447)-C(5))-methyltransferase
- UniProt
- P46087
- Pockets
- 1 · best druggability 0.57
Structure
1 distinct chain · 22% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable 28S rRNA (CYTOSINE(4447)-C(5))-methyltransferase | protein | 812 | 22% helix, 8% strand | P46087 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 310 | 0.57 | 0.76 | 49 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 8FKV · Human nucleolar pre-60S ribosomal subunit (State D1) · an experimental structure of the same protein · chain A against SY, TM-score 0.46
- 8FKW · Human nucleolar pre-60S ribosomal subunit (State D2) · an experimental structure of the same protein · chain A against SY, TM-score 0.46
- 8FKU · Human nucleolar pre-60S ribosomal subunit (State C2) · an experimental structure of the same protein · chain A against SY, TM-score 0.46
- 8FKT · Human nucleolar pre-60S ribosomal subunit (State C1) · an experimental structure of the same protein · chain A against SY, TM-score 0.46
- 8FKY · Human nucleolar pre-60S ribosomal subunit (State F) · an experimental structure of the same protein · chain A against SY, TM-score 0.46
- 8FKX · Human nucleolar pre-60S ribosomal subunit (State E) · an experimental structure of the same protein · chain A against SY, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46087
- Elsewhere: UniProt P46087 · AlphaFold DB P46087
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