MolNFT v1 · #266297 · protein
AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2C (Q00961)
Q00961: “AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2C (Q00961)”. 15 pockets (best druggability 0.74). MolNFT v1 #266297 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q00961
- Type
- protein
- Length
- 1,237 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x78a503a9F23864BFbc868D392a218431330dD1fd
- Molecule
- Glutamate receptor ionotropic, NMDA 2C
- UniProt
- Q00961
- Pockets
- 15 · best druggability 0.74
Structure
1 distinct chain · 33% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor ionotropic, NMDA 2C | protein | 1237 | 33% helix, 12% strand | Q00961 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 303 | 0.74 | 0.86 | 39 | empty |
| 2 | 250 | 0.73 | 0.87 | 37 | empty |
| 3 | 312 | 0.58 | 0.77 | 47 | empty |
| 4 | 107 | 0.55 | 0.84 | 21 | empty |
| 5 | 208 | 0.55 | 0.79 | 39 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7YFI · Structure of the Rat tri-heteromeric GluN1-GluN2A-GluN2C NMDA receptor in complex with… · an experimental structure of the same protein · chain A against D, TM-score 0.53
- 7YFG · Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate… · an experimental structure of the same protein · chain A against D, TM-score 0.47
- 8HDK · Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate… · an experimental structure of the same protein · chain A against D, TM-score 0.47
- 7YFH · Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine, glutamate and… · an experimental structure of the same protein · chain A against D, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00961
- Elsewhere: UniProt Q00961 · AlphaFold DB Q00961
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